This article points out how Amerindian net-activism is articulated in digital media, taking into account ethnic diversity and social vulnerabilities, during the pandemic period. Part of the analysis of three Instagram profiles: @midiaindiaoficial, @apiboficial and @visibilidadeindigena. It appears that the publications of these profiles are marked by: I) mobilization and dissemination about care in a pandemic period, vaccination and updating of statistical data (vaccinated, dead and contaminated); II) raising awareness and denouncing violations of Amerindian rights; and III) dissemination of its achievements in the field of arts, studies, legislation, among others. The authors argue that native peoples started to inhabit these digital spaces, as ecology, both of struggle and resistance.